This cohort includes 153 families (690 individuals) who provided DNA samples. Most have results for a 400 marker genome screen. Phenotypes of family members were classified with data from four sources (otomicroscopic exams, multifrequency tympanometry, self (or parent reported) otitis media history, and medical record information on otitis media) using predefined criteria. There are an additional 400+ individuals who have clinical data, but did not participate in the DNA portion of the study. The database includes >2100 ear exams and tympanograms, >2500 histories, and >1000 medical record abstracts. For more detail on variables collected, see Genetic Study Forms, Genetic Data Dictionaries.
Examples of Research:
Daly KA, Brown WM, Segade F, Bowden DW, Keats BJ, Lindgren BR, Levine SC, Rich SS. Chronic and Recurrent Otitis Media: A Genome Scan for Susceptibility Loci. Am J Hum Genet, 75:988-997, 2004.
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